Presentation of ligands on hydroxylapatite.

نویسندگان

  • B C Chu
  • L E Orgel
چکیده

Conjugates of biotin with the decamer of glutamic acid (glu10) and the trimer of D,L-2-amino-5-phosphonovaleric acid (I) have been synthesized, and it has been shown that they mediate the binding of avidin to hydroxylapatite. In a similar way a conjugate of methotrexate with glu10 mediates the binding of dihydrofolate reducatase to the mineral. The presentation of ligands on the hydroxylapatite component of bone may find applications in clinical medicine.

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عنوان ژورنال:
  • Bioconjugate chemistry

دوره 8 2  شماره 

صفحات  -

تاریخ انتشار 1997